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Clinical Experience with Routine Gd-DTPA Administration for MR Imaging of the Brain J Comput Assist Tomogr 14:11-17, Schwaighofer,B.W.,et al, 1990 See this aricle in Pubmed Article Abstract A retrospective analysis of intracranial magnetic resonance(MR scans of 514 patients who underwent nonselective Gd-DTPA enhanced MR imaging)was performed to determine the efficacy of this protocol for Gd-DTPA administration.This report reviews the frequency and clinical significance of abnormally enhancing areas that were entirely undetectable on precontrast images or would have been missed without the retrospective knowledge of enhancement.Fifty-seven patients(11%of the 514 patients studied)showed enhancing lesions,with 16(3.1%of the total)of these patients demonstrating one or more lesions identifiable only on postcontrast images.Of those 16 patients,8 had other focal abnormalities on precontrast studies,whereas the remaining 8(1.6%of the total)had negative precontrast studies.The new diagnoses affected clinical management directly in five patients and in another nine contributed potentially significant information.Considerations regarding a selective versus nonselective protocol for Gd-DTPA administration for intracranial MR imaging and the use of clinical information to augment these protocols are discussed.

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(click to filter results - removes previous filter) gadolinium MRI MRI,abnormal MRI,contrast enhanced MRI,false negative

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